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    mAChR-A muscarinic Acetylcholine Receptor, A-type [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37892, updated on 10-May-2024

    Summary

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    Official Symbol
    mAChR-Aprovided by FlyBase
    Official Full Name
    muscarinic Acetylcholine Receptor, A-typeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000037
    Locus tag
    Dmel_CG4356
    See related
    AllianceGenome:FB:FBgn0000037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Acr60C; AcrC; CG4356; Dm-mAChR-A; Dm1; DM1; Dmel\CG4356; mAchR; mAChR; mAChR A; mAChR-1; mAChR-A1; mAcR; mAcR-60C; mAcR60C
    Summary
    Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and phospholipase C-activating G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; autoimmune disease of the nervous system (multiple); heroin dependence; lung disease (multiple); and prune belly syndrome. Orthologous to several human genes including CHRM1 (cholinergic receptor muscarinic 1); CHRM3 (cholinergic receptor muscarinic 3); and CHRM5 (cholinergic receptor muscarinic 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mAChR-A in Genome Data Viewer
    Location:
    60C7-60C7; 2-106 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24378630..24390294, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20266153..20277817, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene blistered Neighboring gene blistered anti-sense lncRNA Neighboring gene transfer RNA:Asparagine-GTT 1-9 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44813 Neighboring gene Sterile20-like kinase Neighboring gene Regulatory particle non-ATPase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GPCR voltage dependence controls neuronal plasticity and behavior. Rozenfeld E, et al. Nat Commun, 2021 Dec 13. PMID 34903750, Free PMC Article
    2. Muscarinic Modulation of Antennal Lobe GABAergic Local Neurons Shapes Odor Coding and Behavior. Rozenfeld E, et al. Cell Rep, 2019 Dec 3. PMID 31801087, Free PMC Article
    3. Pharmacological identification of cholinergic receptor subtypes on Drosophila melanogaster larval heart. Malloy CA, et al. J Comp Physiol B, 2016 Jan. PMID 26438517
    4. Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists. Honda H, et al. J Agric Food Chem, 2007 Mar 21. PMID 17319687
    5. Spatiotemporal calcium signaling in a Drosophila melanogaster cell line stably expressing a Drosophila muscarinic acetylcholine receptor. Cordova D, et al. Invert Neurosci, 2003 Nov. PMID 12827518

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in the Drosophila larval locomotor network.
      Title: Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in the Drosophila larval locomotor network.
    2. mAChR-A function in Kenyon cell dendrites is required for synaptic plasticity between Kenyon cells and their output neurons.
      Title: Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled acetylcholine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled acetylcholine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled amine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    muscarinic acetylcholine Receptor, A-type
    Names
    A-type mAChR
    CG4356-PA
    CG4356-PB
    mAChR-A-PA
    mAChR-A-PB
    muscarinic acetylcholine receptor
    muscarinic acetylcholine receptor 60C
    muscarinic receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24378630..24390294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166668.2 → NP_726440.1  muscarinic acetylcholine Receptor, A-type, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16395
      Related
      FBpp0072274
      Conserved Domains (2) summary
      pfam00001
      Location:121 → 314
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:117 → 241
      7tm_4; Olfactory receptor

    2. NM_079120.3 → NP_523844.2  muscarinic acetylcholine Receptor, A-type, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523844.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G4LU59, M9NHK8, M9NKN3, P16395, Q1ECB8, Q8MLP2, Q9W180
      Related
      FBpp0072275
      Conserved Domains (2) summary
      pfam00001
      Location:121 → 314
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:117 → 241
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16395.2 P16395

    Gene LinkOut

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