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    casp8.L caspase 8 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 373559, updated on 11-Apr-2024

    Summary

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    Official Symbol
    casp8.L
    Official Full Name
    caspase 8 L homeolog
    Primary source
    Xenbase:XB-GENE-865733
    Locus tag
    XELAEV_18044911mg
    See related
    EnsemblRapid:ENSXLAG00005025559
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    casp8; casp8-A; xCaspase-8
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    Genomic context

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    See casp8.L in Genome Data Viewer
    Location:
    chromosome: 9_10L
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (88373354..88395056)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (77782349..77804128)

    Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene caspase 10 L homeolog Neighboring gene caspase-8-like Neighboring gene STE20-related kinase adapter protein beta Neighboring gene transmembrane protein 237 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Occurrence of pre-MBT synthesis of caspase-8 mRNA and activation of caspase-8 prior to execution of SAMDC (S-adenosylmethionine decarboxylase)-induced, but not p53-induced, apoptosis in Xenopus late blastulae. Shiokawa K, et al. Biochem Biophys Res Commun, 2005 Oct 21. PMID 16143307
    2. Developmental cell death during Xenopus metamorphosis involves BID cleavage and caspase 2 and 8 activation. Du Pasquier D, et al. Dev Dyn, 2006 Aug. PMID 16786588
    3. Structure, expression, and function of the Xenopus laevis caspase family. Nakajima K, et al. J Biol Chem, 2000 Apr 7. PMID 10744739
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos.
      Title: Occurrence of pre-MBT synthesis of caspase-8 mRNA and activation of caspase-8 prior to execution of SAMDC (S-adenosylmethionine decarboxylase)-induced, but not p53-induced, apoptosis in Xenopus late blastulae.
    2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist and Caspases-2 and -8
      Title: Developmental cell death during Xenopus metamorphosis involves BID cleavage and caspase 2 and 8 activation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    caspase 8 L homeolog
    Names
    caspase 8, apoptosis-related cysteine peptidase
    caspase-8
    xcaspase 8
    NP_001079034.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085565.1 → NP_001079034.1  caspase 8 L homeolog

      See identical proteins and their annotated locations for NP_001079034.1

      Status: PROVISIONAL

      Source sequence(s)
      AB038171
      UniProtKB/TrEMBL
      A0A974H3S8, Q9IB64
      Related
      ENSXLAP00005076011.1, ENSXLAT00005077591.1
      Conserved Domains (3) summary
      cd00032
      Location:252 → 495
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:17 → 98
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cd08334
      Location:110 → 190
      DED_Caspase_8_10_r2; Death effector domain, repeat 2, of initator caspases 8 and 10

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      88373354..88395056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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