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    LINC00265 long intergenic non-protein coding RNA 265 [ Homo sapiens (human) ]

    Gene ID: 349114, updated on 5-Feb-2024

    Summary

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    Official Symbol
    LINC00265provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 265provided by HGNC
    Primary source
    HGNC:HGNC:28019
    See related
    AllianceGenome:HGNC:28019
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCRNA00265
    Expression
    Broad expression in testis (RPKM 10.9), bone marrow (RPKM 2.5) and 21 other tissues See more
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    Genomic context

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    See LINC00265 in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (39733568..39794623)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (39891132..39952175)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (39773167..39834222)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986785 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39663047-39663894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25879 Neighboring gene RAS like proto-oncogene A Neighboring gene Sharpr-MPRA regulatory region 6412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25880 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39761893-39762394 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:39762968-39763530 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39763531-39764091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25882 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:39772987-39774186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25881 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39774391-39775162 Neighboring gene NANOG hESC enhancer GRCh37_chr7:39789308-39790145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:39793752-39794419 Neighboring gene RNA, U6 small nuclear 719, pseudogene Neighboring gene capicua transcriptional repressor pseudogene 22 Neighboring gene uncharacterized LOC101928688 Neighboring gene pleckstrin homology domain containing B2 pseudogene Neighboring gene SSBP3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA LINC00265 promotes proliferation, apoptosis, and inflammation of chondrocytes in osteoarthritis by sponging miR-101-3p. Zou H, et al. Autoimmunity, 2021 Dec. PMID 34633248
    2. LINC00265 targets miR-382-5p to regulate SAT1, VAV3 and angiogenesis in osteosarcoma. Xiao Y, et al. Aging (Albany NY), 2020 Aug 14. PMID 33109774, Free PMC Article
    3. Long noncoding RNA LINC00265 predicts the prognosis of acute myeloid leukemia patients and functions as a promoter by activating PI3K-AKT pathway. Ma L, et al. Eur Rev Med Pharmacol Sci, 2018 Nov. PMID 30536332
    4. LINC00265 maintains hepatocyte proliferation during liver regeneration by targeting miRNA-28-5p. Yu S, et al. Biosci Biotechnol Biochem, 2021 Feb 24. PMID 33624782
    5. LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-catenin. Zhu Y, et al. Cell Death Differ, 2020 Apr. PMID 31527801, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Transcription Factor ZNF384, Regulated by LINC00265, Activates the Expression of IFI30 to Stimulate Malignant Progression in Glioma.
      Title: A Transcription Factor ZNF384, Regulated by LINC00265, Activates the Expression of IFI30 to Stimulate Malignant Progression in Glioma.
    2. Long non-coding RNA LINC00265 promotes proliferation, apoptosis, and inflammation of chondrocytes in osteoarthritis by sponging miR-101-3p.
      Title: Long non-coding RNA LINC00265 promotes proliferation, apoptosis, and inflammation of chondrocytes in osteoarthritis by sponging miR-101-3p.
    3. LINC00265 maintains hepatocyte proliferation during liver regeneration by targeting miRNA-28-5p.
      Title: LINC00265 maintains hepatocyte proliferation during liver regeneration by targeting miRNA-28-5p.
    4. LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of beta-catenin.
      Title: LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-catenin.
    5. LINC00265 targets miR-382-5p to regulate SAT1, VAV3 and angiogenesis in osteosarcoma.
      Title: LINC00265 targets miR-382-5p to regulate SAT1, VAV3 and angiogenesis in osteosarcoma.
    6. overexpression of LINC00265 suppressed the capability of proliferation, migration and invasion in acute myeloid leukemia cell lines. By using Western blot, further illustrated that LINC00265 activated PI3K/AKT signaling in AML cell lines.
      Title: Long noncoding RNA LINC00265 predicts the prognosis of acute myeloid leukemia patients and functions as a promoter by activating PI3K-AKT pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • NCRNA00265-1

    Clone Names

    • AC004987.7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026999.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004837, AC004987, AI304809, BC038571, BC053841, DA726117

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      39733568..39794623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      39891132..39952175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198284.1: Suppressed sequence

      Description
      NM_198284.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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