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    Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 330064, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Slc5a6provided by MGI
    Official Full Name
    solute carrier family 5 (sodium-dependent vitamin transporter), member 6provided by MGI
    Primary source
    MGI:MGI:2660847
    See related
    Ensembl:ENSMUSG00000006641 AllianceGenome:MGI:2660847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E430023I20
    Summary
    Predicted to enable biotin transmembrane transporter activity; pantothenate transmembrane transporter activity; and sodium-dependent multivitamin transmembrane transporter activity. Predicted to be involved in anion transmembrane transport; sodium ion transport; and transport across blood-brain barrier. Predicted to act upstream of or within ion transport. Predicted to be located in brush border membrane and vesicle membrane. Is expressed in several structures, including 4-cell stage embryo; choroid plexus; pericardium; pituitary gland; and skeletal musculature. Orthologous to human SLC5A6 (solute carrier family 5 member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 20.8), large intestine adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc5a6 in Genome Data Viewer
    Location:
    5 B1; 5 16.93 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31193380..31206268, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31036036..31048924, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding Neighboring gene transcription factor 23 Neighboring gene STARR-seq mESC enhancer starr_12765 Neighboring gene STARR-positive B cell enhancer ABC_E2741 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene predicted gene, 38601

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota. Sabui S, et al. Am J Physiol Gastrointest Liver Physiol, 2019 Oct 1. PMID 31369292, Free PMC Article
    2. Biotin and pantothenic acid oversupplementation to conditional SLC5A6 KO mice prevents the development of intestinal mucosal abnormalities and growth defects. Sabui S, et al. Am J Physiol Cell Physiol, 2018 Jul 1. PMID 29669219, Free PMC Article
    3. Role of the sodium-dependent multivitamin transporter (SMVT) in the maintenance of intestinal mucosal integrity. Sabui S, et al. Am J Physiol Gastrointest Liver Physiol, 2016 Sep 1. PMID 27492331, Free PMC Article
    4. Chronic alcohol exposure inhibits biotin uptake by pancreatic acinar cells: possible involvement of epigenetic mechanisms. Srinivasan P, et al. Am J Physiol Gastrointest Liver Physiol, 2014 Nov 1. PMID 25214397, Free PMC Article
    5. Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption. Ghosal A, et al. Am J Physiol Gastrointest Liver Physiol, 2013 Jan 1. PMID 23104561, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study shows for the first time that LPS inhibits colonic biotin uptake via decreasing membrane expression of its transporter and that these effects likely involve a CK2-mediated pathway.
      Title: Lipopolysaccharide inhibits colonic biotin uptake via interference with membrane expression of its transporter: a role for a casein kinase 2-mediated pathway.
    2. S. typhimurium infection inhibits intestinal biotin uptake by SLC5A6, and that the inhibition is mediated via the action of proinflammatory cytokines.
      Title: Salmonella infection inhibits intestinal biotin transport: cellular and molecular mechanisms.
    3. These studies also provide evidence for a casual association between SMVT function and normal intestinal health
      Title: Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109689

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables biotin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iodide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monocarboxylate:sodium symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pantothenate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pantothenate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pantothenate:sodium symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sodium-dependent multivitamin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium-dependent multivitamin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sodium-dependent multivitamin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfur compound transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitamin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables vitamin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biotin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biotin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biotin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iodide transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pantothenate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pantothenate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pantothenate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent multivitamin transporter
    Names
    Na(+)-dependent multivitamin transporter
    solute carrier family 5 member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177621.1 → NP_001171092.1  sodium-dependent multivitamin transporter

      See identical proteins and their annotated locations for NP_001171092.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AK158896, BC085132
      Consensus CDS
      CCDS19169.1
      UniProtKB/Swiss-Prot
      Q5U4D8, Q8BTU3
      UniProtKB/TrEMBL
      Q3TY45
      Related
      ENSMUSP00000110316.2, ENSMUST00000114668.7
      Conserved Domains (1) summary
      cl00456
      Location:23 → 548
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001177622.1 → NP_001171093.1  sodium-dependent multivitamin transporter

      See identical proteins and their annotated locations for NP_001171093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      BC065061, BC085132
      Consensus CDS
      CCDS19169.1
      UniProtKB/Swiss-Prot
      Q5U4D8, Q8BTU3
      UniProtKB/TrEMBL
      Q3TY45
      Related
      ENSMUSP00000079291.2, ENSMUST00000080431.8
      Conserved Domains (1) summary
      cl00456
      Location:23 → 548
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_001360022.1 → NP_001346951.1  sodium-dependent multivitamin transporter

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC109608
      Consensus CDS
      CCDS19169.1
      UniProtKB/Swiss-Prot
      Q5U4D8, Q8BTU3
      UniProtKB/TrEMBL
      Q3TY45
      Related
      ENSMUSP00000143993.2, ENSMUST00000202556.4
      Conserved Domains (1) summary
      cl00456
      Location:23 → 548
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_177870.5 → NP_808538.1  sodium-dependent multivitamin transporter

      See identical proteins and their annotated locations for NP_808538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC109608, AK161633, BC085132
      Consensus CDS
      CCDS19169.1
      UniProtKB/Swiss-Prot
      Q5U4D8, Q8BTU3
      UniProtKB/TrEMBL
      Q3TY45
      Related
      ENSMUSP00000143938.2, ENSMUST00000202520.4
      Conserved Domains (1) summary
      cl00456
      Location:23 → 548
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31193380..31206268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U4D8.2 GenPept UniProtKB/Swiss-Prot:Q5U4D8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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