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    tlk1b tousled-like kinase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 326734, updated on 27-Mar-2024

    Summary

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    Official Symbol
    tlk1bprovided by ZNC
    Official Full Name
    tousled-like kinase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4933
    See related
    Ensembl:ENSDARG00000100715 AllianceGenome:ZFIN:ZDB-GENE-030131-4933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tlk1; fe11e12; wu:fe11e12; si:dkey-251e16.4
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of chromatin assembly or disassembly. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Orthologous to human TLK1 (tousled like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See tlk1b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (3877673..3924738, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (3716853..3763922, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene glutamate decarboxylase 1b Neighboring gene golgi reassembly stacking protein 2 Neighboring gene dynein, cytoplasmic 1, intermediate chain 2b Neighboring gene solute carrier family 25 member 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Gebauer JM, et al. Matrix Biol, 2016 Jan. PMID 26235539
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase tousled-like 1-B
    Names
    pKU-beta protein kinase
    tousled-like kinase 1
    tousled-like kinase 1-B
    NP_001020122.2
    XP_017211931.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024951.2 → NP_001020122.2  serine/threonine-protein kinase tousled-like 1-B

      Status: VALIDATED

      Source sequence(s)
      CR384078
      UniProtKB/Swiss-Prot
      Q90ZY6
      UniProtKB/TrEMBL
      A0A8M1N705, F1QH83
      Related
      ENSDARP00000136032.1, ENSDART00000171804.2
      Conserved Domains (2) summary
      smart00220
      Location:461 → 728
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14040
      Location:443 → 741
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      3877673..3924738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017356442.2 → XP_017211931.1  serine/threonine-protein kinase tousled-like 1-B isoform X1

      UniProtKB/Swiss-Prot
      Q90ZY6
      UniProtKB/TrEMBL
      A0A0R4IQ51, A0A8M6YYP0
      Related
      ENSDARP00000137516.1, ENSDART00000170584.2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90ZY6.1 GenPept UniProtKB/Swiss-Prot:Q90ZY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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