pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3r5provided by ZNC
Official Full Name: phosphoinositide-3-kinase, regulatory subunit 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2308
See related: Ensembl:ENSDARG00000102762 AllianceGenome:ZFIN:ZDB-GENE-030131-2308
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc03h05; wu:fc03h05; si:ch73-203d16.1
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and positive regulation of MAP kinase activity. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (19933728..19979293)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (23462433..23507888)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

fc03h05.x1 (e-PCR)
- UniSTS:203688

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IB	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoinositide 3-kinase regulatory subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

19933728..19979293

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477349.1 → XP_021333024.1 phosphoinositide 3-kinase regulatory subunit 5 isoform X1

UniProtKB/TrEMBL

A0A0R4IPI8, A0A8M9Q7E2

Related

ENSDARP00000148730.1, ENSDART00000181632.1

Conserved Domains (1) summary

pfam10486
Location:4 → 874

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394639.1 Reference GRCz11 ALT_DRER_TU_1

Range

170639..222325

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009302367.3 → XP_009300642.2 phosphoinositide 3-kinase regulatory subunit 5 isoform X2

UniProtKB/TrEMBL

A0A0R4IPI8, A0A8M3BAC9

Conserved Domains (1) summary

pfam10486
Location:4 → 865

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit