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    Dop1b DOP1 leucine zipper like protein B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304077, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Dop1bprovided by RGD
    Official Full Name
    DOP1 leucine zipper like protein Bprovided by RGD
    Primary source
    RGD:1306097
    See related
    Ensembl:ENSRNOG00000051204 AllianceGenome:RGD:1306097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dopey2; RGD1306097
    Summary
    Predicted to be involved in cognition. Predicted to be located in early endosome membrane. Predicted to be active in endosome and trans-Golgi network. Orthologous to human DOP1B (DOP1 leucine zipper like protein B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 64.1), Lung (RPKM 63.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dop1b in Genome Data Viewer
    Location:
    11q11
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (46494058..46595601)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (33024376..33125931)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (33929142..34027447)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene carbonyl reductase 1 like 3 Neighboring gene carbonyl reductase 3 Neighboring gene interferon induced transmembrane protein 7 Neighboring gene MORC family CW-type zinc finger 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Swaminathan S, et al. PLoS One, 2012. PMID 23227193, Free PMC Article
    2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein dopey-2
    Names
    dopey family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191660.2 → NP_001178589.2  protein dopey-2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A0G2JXD9
      Related
      ENSRNOP00000070233.2, ENSRNOT00000083594.2
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1948 → 2096
      Dopey_N; Dopey, N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      46494058..46595601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088417.2 → XP_038944345.1  protein dopey-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXD9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1960 → 2108
      Dopey_N; Dopey, N-terminal

    RNA

    1. XR_005491035.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.