PLAT plasminogen activator, tissue type [Bos taurus (cattle)] - Gene

Summary

Official Symbol: PLATprovided by VGNC
Official Full Name: plasminogen activator, tissue typeprovided by VGNC
Primary source: VGNC:VGNC:32974
See related: BGD:BT10501; Ensembl:ENSBTAG00000001244
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	27	NC_037354.1 (37053712..37077724, complement)

Chromosome 27 - NC_037354.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasminogen activator, tissue type regulates germinal vesicle breakdown and cumulus expansion of bovine cumulus-oocyte complex in vitrodagger.
Title: Plasminogen activator, tissue type regulates germinal vesicle breakdown and cumulus expansion of bovine cumulus-oocyte complex in vitro†.
The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
Title: Fertilization outcome could be regulated by binding of oviductal plasminogen to oocytes and by releasing of plasminogen activators during interplay between gametes.
stage-dependent regulation of granulosa cell PA and SerpinE2 production, consistent with a role in extracellular matrix remodeling during follicle growth
Title: Plasminogen activator and serine protease inhibitor-E2 (protease nexin-1) expression by bovine granulosa cells in vitro.
These results suggest that Neovastat induces tPA gene transcription through activation of the JNK and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.
Title: Activation of tissue plasminogen activator gene transcription by Neovastat, a multifunctional antiangiogenic agent.

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General gene information

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Markers

PLAT (e-PCR)
- UniSTS:251598

PLAT-1 (e-PCR), detects polymorphism
- UniSTS:251598

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in smooth muscle cell migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tissue-type plasminogen activator

Names: t-PA; t-plasminogen activator; tPA; tissue plasminogen activator

NP_776571.2

EC 3.4.21.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174146.3 → NP_776571.2 tissue-type plasminogen activator precursor

See identical proteins and their annotated locations for NP_776571.2

Status: PROVISIONAL

Source sequence(s)

BC105348

UniProtKB/Swiss-Prot

Q28198, Q2KJG9

Related

ENSBTAP00000103917.1, ENSBTAT00000092963.1

Conserved Domains (4) summary

smart00020
Location:314 → 560

Tryp_SPc; Trypsin-like serine protease

smart00058
Location:42 → 84

FN1; Fibronectin type 1 domain

cd00108
Location:216 → 300

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:317 → 563

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...