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    PAEP progestagen-associated endometrial protein [ Bos taurus (cattle) ]

    Gene ID: 280838, updated on 4-Apr-2024

    Summary

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    Gene symbol
    PAEP
    Gene description
    progestagen-associated endometrial protein
    See related
    BGD:BT10129; Ensembl:ENSBTAG00000014678
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BLG; LGB
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    Genomic context

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    See PAEP in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (103255756..103260862)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene odorant-binding protein 2b Neighboring gene beta-lactoglobulin-2 Neighboring gene glycosyltransferase 6 domain containing 1 Neighboring gene lipocalin 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. β-Lactoglobulin Influences Human Immunity and Promotes Cell Proliferation. Tai CS, et al. Biomed Res Int, 2016. PMID 27957499, Free PMC Article
    2. Energetic and conformational features linked to the monomeric and dimeric states of bovine BLG. Bello M, et al. Int J Biol Macromol, 2016 Nov. PMID 27456117
    3. Effect of supplementation of cows diet with linseed and fish oil and different variants of β-lactoglobulin on fatty acid composition and antioxidant capacity of milk. Puppel K, et al. J Sci Food Agric, 2016 Apr. PMID 26174000
    4. Ultra-high resolution crystal structure of recombinant caprine β-lactoglobulin. Crowther JM, et al. FEBS Lett, 2014 Nov 3. PMID 25241165
    5. Energetics of intermolecular hydrogen bonds in a hydrophobic protein cavity. Liu L, et al. J Am Soc Mass Spectrom, 2014 May. PMID 24658798

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the conformational complexity of BLG protein-protein self-association and palmitic acid (PLM) or dodecyl sulfate (SDS) ligand recognition in the monomeric and dimeric state, was investigated.
      Title: Energetic and conformational features linked to the monomeric and dimeric states of bovine BLG.
    2. The effect of beta-lactoglobulin (beta-LG) phenotype on the fatty acid composition and antioxidant capacity of milk is variable, which could partly be the result of a beta-LG phenotype x diet interaction.
      Title: Effect of supplementation of cows diet with linseed and fish oil and different variants of β-lactoglobulin on fatty acid composition and antioxidant capacity of milk.
    3. LG plays a key role in enhancing immune responses by promoting cell proliferation through IgM receptor.
      Title: β-Lactoglobulin Influences Human Immunity and Promotes Cell Proliferation.
    4. Interactions of LGB-A and LGB-B with sodium dodecyl sulfate, dodecyltrimethylammonium chloride and lauric acid, 12-carbon ligands possessing differently charged polar groups, were investigated.[LGB-A, LGB-B]
      Title: The differences in binding 12-carbon aliphatic ligands by bovine β-lactoglobulin isoform A and B studied by isothermal titration calorimetry and X-ray crystallography.
    5. Data (including data from molecular dynamic simulations) suggest that -OH groups of 3-hydroxypalmitic acid and 16-hydroxypalmitic acid act as hydrogen-bond donors in a hydrophobic protein cavity of beta-lactoglobulin. [BLG, beta-lactoglobulin]
      Title: Energetics of intermolecular hydrogen bonds in a hydrophobic protein cavity.
    6. SNPs at the exon2 region of the beta-LG gene affected milk performance traits in Chinese Holstein cattle.
      Title: [The effect of genetic polymorphism of the exon 2 of the beta-lactoglobulin gene on the milk composition in Chinese Holstein].
    7. Rate constants (k(off)) for betaLg dimer dissociation, were estimated.
      Title: Bovine β-lactoglobulin is dimeric under imitative physiological conditions: dissociation equilibrium and rate constants over the pH range of 2.5-7.5.
    8. Because of a more favorable enthalpy, the dimerization equilibrium constant of beta-LG B was larger than that of beta-LG A at room temperature, while the two dimers became similarly stable at 35 degrees C.
      Title: Energetics of ligand recognition and self-association of bovine β-lactoglobulin: differences between variants A and B.
    9. Three single nucleotide polymorphisms change beta-LG B* gene structure and expression.
      Title: Polymorphism in the exon 4 of β-lactoglobulin variant B precursor gene and its association with milk traits and protein structure in Chinese Holstein.
    10. Kinetic studies of the interaction of beta-lactoglobulin with model membranes: stopped-flow CD and fluorescence studies.
      Title: Kinetic studies of the interaction of β-lactoglobulin with model membranes: stopped-flow CD and fluorescence studies.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC134239

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-lactoglobulin
    Names
    bLG C
    beta lactoglobulin C
    beta lactoglobulin D
    beta-LG
    lactoglobulin, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173929.3 → NP_776354.2  beta-lactoglobulin precursor

      See identical proteins and their annotated locations for NP_776354.2

      Status: PROVISIONAL

      Source sequence(s)
      BC108213
      UniProtKB/Swiss-Prot
      P02754, Q32P89
      UniProtKB/TrEMBL
      B5B0D4
      Conserved Domains (1) summary
      cd19416
      Location:19 → 178
      lipocalin_beta-LG-like; beta-lactoglobulin and similar proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      103255756..103260862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015473597.3 → XP_015329083.3  beta-lactoglobulin isoform X1

      Related
      ENSBTAP00000019538.7, ENSBTAT00000019538.7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02754.3 GenPept UniProtKB/Swiss-Prot:P02754

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials
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