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    MOB4 MOB family member 4, phocein [ Homo sapiens (human) ]

    Gene ID: 25843, updated on 2-May-2024

    Summary

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    Official Symbol
    MOB4provided by HGNC
    Official Full Name
    MOB family member 4, phoceinprovided by HGNC
    Primary source
    HGNC:HGNC:17261
    See related
    Ensembl:ENSG00000115540 MIM:609361; AllianceGenome:HGNC:17261
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2C4D; MOB1; MOB3; PHOCN; PREI3; CGI-95; MOBKL3
    Summary
    This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in adrenal (RPKM 20.9), esophagus (RPKM 14.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MOB4 in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (197515554..197553699)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (197999154..198037300)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (198380278..198418423)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 105B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16939 Neighboring gene HSPE1-MOB4 readthrough Neighboring gene heat shock protein family D (Hsp60) member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12215 Neighboring gene heat shock protein family E (Hsp10) member 1 Neighboring gene uncharacterized LOC124907952 Neighboring gene RNY5 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:198447337-198447852 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:198451577-198452275 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:198452276-198452973 Neighboring gene raftlin family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16940 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198484019-198484523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:198484980-198485480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198532470-198533059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198533060-198533648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16943 Neighboring gene methionyl-tRNA synthetase 2, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Phocein: A potential actor in vesicular trafficking at Purkinje cell dendritic spines. Bailly YJ, et al. Cerebellum, 2007. PMID 17853115
    2. hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme. Tang F, et al. Cancer Res, 2014 Jul 15. PMID 24872389, Free PMC Article
    3. Cryo-EM structure of the Hippo signaling integrator human STRIPAK. Jeong BC, et al. Nat Struct Mol Biol, 2021 Mar. PMID 33633399, Free PMC Article
    4. The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. Chen M, et al. J Biol Chem, 2018 Sep 14. PMID 30072378, Free PMC Article
    5. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. Moreno CS, et al. J Biol Chem, 2001 Jun 29. PMID 11319234, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mob4 is essential for spermatogenesis in Drosophila melanogaster.
      Title: Mob4 is essential for spermatogenesis in Drosophila melanogaster.
    2. Because of divergent evolution of key interface residues, MST4 and MOB4 could disrupt assembly of the MST1-MOB1 complex through alternative pairing and thereby increased YAP activity. Collectively, these findings identify the MST4-MOB4 complex as a noncanonical regulator of the Hippo-YAP pathway with an oncogenic role in PC
      Title: The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.
    3. hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.
      Title: hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.
    4. phosphorylation of MOB1 at Thr74 by MST2 is essential to make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1
      Title: Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC12264

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MOB-like protein phocein
    Names
    MOB1, Mps One Binder kinase activator-like 3
    Mps One Binder kinase activator-like 3
    class II mMOB1
    mob1 homolog 3
    phocein, Mob-like protein
    preimplantation protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100819.3 → NP_001094289.1  MOB-like protein phocein isoform 3

      See identical proteins and their annotated locations for NP_001094289.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC020550, AK297514, BC005237, CR736874
      Consensus CDS
      CCDS46480.1
      UniProtKB/TrEMBL
      A8K012
      Related
      ENSP00000405354.2, ENST00000448447.6
      Conserved Domains (1) summary
      pfam03637
      Location:32 → 186
      Mob1_phocein; Mob1/phocein family

    2. NM_001204094.1 → NP_001191023.1  MOB-like protein phocein isoform 2

      See identical proteins and their annotated locations for NP_001191023.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate exon at its 5' end compared to variant 1, resulting in a different 5' UTR and translation initiation at a downstream start codon. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AC020550, AK292938, CR736874, DC375649
      Consensus CDS
      CCDS2322.1
      UniProtKB/TrEMBL
      A8K012
      Related
      ENSP00000387289.1, ENST00000409360.1
      Conserved Domains (1) summary
      pfam03637
      Location:21 → 175
      Mob1_phocein; Mob1/phocein family

    3. NM_015387.5 → NP_056202.2  MOB-like protein phocein isoform 1

      See identical proteins and their annotated locations for NP_056202.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC020550, BC005237, CR736874
      Consensus CDS
      CCDS2321.1
      UniProtKB/Swiss-Prot
      B4DML0, Q53SE0, Q7Z4Y6, Q9H2P3, Q9H5J1, Q9Y3A3, Q9Y4T8
      UniProtKB/TrEMBL
      A8K012
      Related
      ENSP00000315702.4, ENST00000323303.9
      Conserved Domains (1) summary
      pfam03637
      Location:53 → 207
      Mob1_phocein; Mob1/phocein family

    4. NM_199482.4 → NP_955776.1  MOB-like protein phocein isoform 2

      See identical proteins and their annotated locations for NP_955776.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon at its 5' end compared to variant 1, resulting in a different 5' UTR and translation initiation at a downstream start codon. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AC020550, AF250319, AL080070, CR736874, DC298610
      Consensus CDS
      CCDS2322.1
      UniProtKB/TrEMBL
      A8K012
      Related
      ENSP00000233892.4, ENST00000233892.8
      Conserved Domains (1) summary
      pfam03637
      Location:21 → 175
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      197515554..197553699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      197999154..198037300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y3A3.1 GenPept UniProtKB/Swiss-Prot:Q9Y3A3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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