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    St8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 225742, updated on 11-Apr-2024

    Summary

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    Official Symbol
    St8sia5provided by MGI
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5provided by MGI
    Primary source
    MGI:MGI:109243
    See related
    Ensembl:ENSMUSG00000025425 AllianceGenome:MGI:109243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat8e; ST8SiaV
    Summary
    Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in glycoprotein metabolic process; glycosphingolipid biosynthetic process; and oligosaccharide metabolic process. Predicted to be located in Golgi membrane. Is expressed in brain. Orthologous to human ST8SIA5 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 39.0), cortex adult (RPKM 14.8) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St8sia5 in Genome Data Viewer
    Location:
    18 E3; 18 52.13 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77273529..77343146)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77185847..77255450)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930520E11 gene Neighboring gene protein inhibitor of activated STAT 2 Neighboring gene STARR-seq mESC enhancer starr_45110 Neighboring gene STARR-seq mESC enhancer starr_45112 Neighboring gene STARR-seq mESC enhancer starr_45115 Neighboring gene predicted gene 7276 Neighboring gene STARR-seq mESC enhancer starr_45117 Neighboring gene lipoxygenase homology domains 1 Neighboring gene USP6 N-terminal like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells. Kwak DH, et al. BMB Rep, 2011 Dec. PMID 22189683
    2. Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3. Kono M, et al. J Biol Chem, 1996 Nov 15. PMID 8910600
    3. Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR. Takashima S, et al. Biochem Biophys Res Commun, 1999 Jun 24. PMID 10381338
    4. Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. Ngamukote S, et al. J Neurochem, 2007 Dec. PMID 17883393
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC41119

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2,8-sialyltransferase 8E
    Names
    SIAT8-E
    sialyltransferase 8 (alpha-2, 8-sialyltransferase) E
    sialyltransferase 8E
    sialyltransferase St8Sia V
    sialytransferase St8Sia V
    NP_038694.2
    NP_694764.2
    XP_006526492.1
    XP_006526493.1
    XP_006526494.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013666.3 → NP_038694.2  alpha-2,8-sialyltransferase 8E isoform long

      See identical proteins and their annotated locations for NP_038694.2

      Status: VALIDATED

      Source sequence(s)
      AC157991
      Consensus CDS
      CCDS50325.1
      UniProtKB/Swiss-Prot
      E9QKY5, P70126, P70127, P70128
      UniProtKB/TrEMBL
      Q8JZQ3
      Related
      ENSMUSP00000074764.7, ENSMUST00000075290.8
      Conserved Domains (1) summary
      pfam00777
      Location:153 → 406
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_153124.3 → NP_694764.2  alpha-2,8-sialyltransferase 8E isoform middle

      See identical proteins and their annotated locations for NP_694764.2

      Status: VALIDATED

      Source sequence(s)
      AC157991
      Consensus CDS
      CCDS29353.1
      UniProtKB/TrEMBL
      Q3TRR3, Q8JZQ3
      Related
      ENSMUSP00000078566.5, ENSMUST00000079618.11
      Conserved Domains (1) summary
      pfam00777
      Location:117 → 370
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      77273529..77343146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526429.5 → XP_006526492.1  alpha-2,8-sialyltransferase 8E isoform X1

      UniProtKB/TrEMBL
      Q8JZQ3
      Conserved Domains (1) summary
      pfam00777
      Location:154 → 407
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_006526430.4 → XP_006526493.1  alpha-2,8-sialyltransferase 8E isoform X2

      UniProtKB/TrEMBL
      Q8JZQ3
      Conserved Domains (1) summary
      pfam00777
      Location:118 → 371
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_006526431.4 → XP_006526494.1  alpha-2,8-sialyltransferase 8E isoform X3

      Conserved Domains (1) summary
      pfam00777
      Location:10 → 222
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177416.1: Suppressed sequence

      Description
      NM_177416.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70126.2 GenPept UniProtKB/Swiss-Prot:P70126

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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