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    Rbmy RNA binding motif protein, Y chromosome [ Mus musculus (house mouse) ]

    Gene ID: 19657, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Rbmyprovided by MGI
    Official Full Name
    RNA binding motif protein, Y chromosomeprovided by MGI
    Primary source
    MGI:MGI:104732
    See related
    Ensembl:ENSMUSG00000094658 AllianceGenome:MGI:104732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RBM; Rbm1; Rbmy1b; Rbmy1a1; Rbm1-rs1; Rbmy1a1-rs1
    Summary
    Predicted to enable identical protein binding activity and mRNA binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in nucleus. Is expressed in central nervous system; sensory organ; and testis. Orthologous to several human genes including RBMY1B (RNA binding motif protein Y-linked family 1 member B); RBMY1D (RNA binding motif protein Y-linked family 1 member D); and RBMY1E (RNA binding motif protein Y-linked family 1 member E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 1.6) See more
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    Genomic context

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    See Rbmy in Genome Data Viewer
    Location:
    Y; Ypter
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (2830680..2841858)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (2830680..2841858)

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene ras homolog gene family, member A pseudogene Neighboring gene predicted gene 8498 Neighboring gene predicted gene 8502 Neighboring gene RNA binding motif protein Y-linked family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability. Pertile MD, et al. Genome Res, 2009 Dec. PMID 19737860, Free PMC Article
    2. The role of human and mouse Y chromosome genes in male infertility. Affara NA, et al. J Endocrinol Invest, 2000 Nov. PMID 11097427
    3. Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}. Dreumont N, et al. J Cell Sci, 2010 Jan 1. PMID 20016065
    4. Identification of target messenger RNA substrates for mouse RBMY. Zeng M, et al. Mol Hum Reprod, 2008 Jun. PMID 18492746
    5. An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells. Elliott DJ, et al. Hum Mol Genet, 1996 Jul. PMID 8817321

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. regulates germline-specific splicing events
      Title: Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}.
    2. mRBMY protein may have high affinity to oligo(A) rich sequences; mRBMY protein can bind to the testis and sperm-specific spa17 mRNA
      Title: Identification of target messenger RNA substrates for mouse RBMY.
    3. RNA transport element RTE evolved as a high affinity RBM15 ligand to provide a splicing-independent link to NXF1, thereby ensuring efficient nuclear export and expression of retrotransposon transcripts
      Title: RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding motif protein, Y chromosome, family 1 member A1
    Names
    RNA binding motif protein, Y chromosome, family 1, member A1, related sequence 1
    RNA-binding motif protein 1
    RNA-binding motif protein, Y chromosome, family 1 member B
    y chromosome RNA recognition motif 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166384.1 → NP_001159856.1  RNA-binding motif protein, Y chromosome, family 1 member A1

      See identical proteins and their annotated locations for NP_001159856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC132601, AK016258
      Consensus CDS
      CCDS30546.1
      UniProtKB/Swiss-Prot
      E9Q856, O35698
      Related
      ENSMUSP00000130080.2, ENSMUST00000171534.8
      Conserved Domains (2) summary
      COG0724
      Location:9 → 85
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:7 → 86
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_011253.2 → NP_035383.2  RNA-binding motif protein, Y chromosome, family 1 member A1

      See identical proteins and their annotated locations for NP_035383.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC132601, AK016258
      Consensus CDS
      CCDS30546.1
      UniProtKB/Swiss-Prot
      E9Q856, O35698
      Related
      ENSMUSP00000097930.4, ENSMUST00000100360.5
      Conserved Domains (2) summary
      COG0724
      Location:9 → 85
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:7 → 86
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      2830680..2841858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35698.2 GenPept UniProtKB/Swiss-Prot:O35698

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