cam-1 Tyrosine-protein kinase receptor cam-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cam-1
Gene description: Tyrosine-protein kinase receptor cam-1
Primary source: WormBase:WBGene00000289
Locus tag: CELE_C01G6.8
See related: AllianceGenome:WB:WBGene00000289
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables Wnt-protein binding activity; frizzled binding activity; and transmembrane receptor protein tyrosine kinase activity. Involved in generation of neurons; neuroblast migration; and peptidyl-tyrosine phosphorylation. Located in several cellular components, including dendrite; neuromuscular junction; and neuronal cell body membrane. Is integral component of plasma membrane. Is expressed in several structures, including QL; head; hypodermis; neurons; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; autosomal recessive nonsyndromic deafness 108; brachydactyly type B1; and cleft palate. Orthologous to human ROR1 (receptor tyrosine kinase like orphan receptor 1) and ROR2 (receptor tyrosine kinase like orphan receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See cam-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (9295915..9310304, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SAX-3 binds to Wnt/CWN-2 and facilitates the membrane recruitment of CWN-2. SAX-3 forms a complex with the Ror/CAM-1 receptor and its downstream effector Dsh/DSH-1.
Title: Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in Caenorhabditis elegans.
Loss of the Frizzled receptor LIN-17 or the planar cell polarity (PCP) protein VANG-1 also caused cross over defects that did not enhance those in the cam-1 mutant, indicating that the proteins function together in midline guidance.. Strong cam-1 expression can be detected in the PVQs and the guidepost cell PVT that is located on the midline
Title: Regulation of Axon Guidance by the Wnt Receptor Ror/CAM-1 in the PVT Guidepost Cell in Caenorhabditis elegans.
Study shows that CAM-1 and the Frizzled receptor MOM-5 act in parallel pathways to control the anterior polarization of the mechanosensory neuron ALM.
Title: Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1.
In a Frizzled-dependent manner, PLR-1 reduces surface levels of the Wnt receptors CAM-1/Ror and LIN-18/Ryk.
Title: The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.
aha-1 and ahr-1 act genetically upstream of cam-1. CAM-1, a membrane-bound receptor tyrosine kinase, is present on both BDU and PLM cells and likely serves as a Wnt antagonist
Title: Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans.
Cell-specific rescue of cam-1 and cell ablation experiments reveal a crucial role for the SIA and SIB neurons in positioning the nerve ring, linking Wnt signaling to specific cells that organize the anterior nervous system.
Title: Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans.
The developmental survival of specific neurites in Caenorhabditis elegans largely depends on detection of the morphogen Wnt by the Ror kinase CAM-1.
Title: A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.
CAM-1 extracellular domain binds to several Wnts in vitro and non-autonomously inhibits the Wnt pathway.
Title: The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway.
CAM-1 negatively regulates EGL-20
Title: The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration.
CAM-1 does not function exclusively as a canonical RTK and that it may function, at least in part, to regulate the distribution of a secreted ligand-possibly a Wnt protein.
Title: Functional analysis of the domains of the C elegans Ror receptor tyrosine kinase CAM-1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2013.4 (e-PCR)
- UniSTS:316476

C01G6.8 (e-PCR)
- UniSTS:321174

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neurotrophin binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nerve growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of neuroblast polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interneuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotrophin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
NOT involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in sensory neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tyrosine-protein kinase receptor cam-1

NP_001021907.1

Confirmed by transcript evidence

NP_001021908.1

Confirmed by transcript evidence

NP_001379452.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9295915..9310304 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393151.1 → NP_001379452.1 Tyrosine-protein kinase receptor cam-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

cd07459
Location:44 → 176

CRD_TK_ROR_like; Cysteine-rich domain of tyrosine kinase-like orphan receptors

smart00130
Location:193 → 272

KR; Kringle domain

cd00192
Location:435 → 699

PTKc; Catalytic domain of Protein Tyrosine Kinases
NM_001026736.5 → NP_001021907.1 Tyrosine-protein kinase receptor cam-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021907.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECA5, G5EGK5, Q38G54

Conserved Domains (6) summary

cd00096
Location:55 → 122

Ig; Immunoglobulin domain

cd07459
Location:203 → 335

CRD_TK_ROR_like; Cysteine-rich domain of tyrosine kinase-like orphan receptors

smart00130
Location:352 → 431

KR; Kringle domain

smart00221
Location:590 → 857

STYKc; Protein kinase; unclassified specificity

pfam07679
Location:39 → 127

I-set; Immunoglobulin I-set domain

cd00192
Location:594 → 858

PTKc; Catalytic domain of Protein Tyrosine Kinases
NM_001026737.6 → NP_001021908.1 Tyrosine-protein kinase receptor cam-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021908.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGK5

Conserved Domains (6) summary

cd00096
Location:29 → 96

Ig; Immunoglobulin domain

cd07459
Location:177 → 309

CRD_TK_ROR_like; Cysteine-rich domain of tyrosine kinase-like orphan receptors

smart00130
Location:326 → 405

KR; Kringle domain

smart00221
Location:564 → 831

STYKc; Protein kinase; unclassified specificity

pfam07679
Location:13 → 101

I-set; Immunoglobulin I-set domain

cd00192
Location:568 → 832

PTKc; Catalytic domain of Protein Tyrosine Kinases