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    NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor [ Macaca nemestrina (pig-tailed macaque) ]

    Gene ID: 105487257, updated on 13-Mar-2024

    Summary

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    Gene symbol
    NF2
    Gene description
    NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
    See related
    Ensembl:ENSMNEG00000038448
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca nemestrina
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NF2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    101 current Mnem_1.0 (GCF_000956065.1) Unplaced Scaffold NW_012010967.1 (2690771..2801576, complement)

    NW_012010967.1Genomic Context describing neighboring genes Neighboring gene cytochrome b-c1 complex subunit 9 Neighboring gene zinc finger matrin-type 5 Neighboring gene calcium binding protein 7 Neighboring gene ribulose-phosphate 3-epimerase-like Neighboring gene ribulose-phosphate 3-epimerase-like Neighboring gene nipsnap homolog 1 Neighboring gene THO complex subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_012010967 Unplaced Scaffold Reference Mnem_1.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of gliogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of organelle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    merlin
    Names
    neurofibromin 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca nemestrina Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mnem_1.0

    Genomic

    1. NW_012010967.1 Reference Mnem_1.0

      Range
      2690771..2801576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011750670.2 → XP_011748972.1  merlin isoform X2

      See identical proteins and their annotated locations for XP_011748972.1

      UniProtKB/TrEMBL
      A0A2K6D227, A0A2K6D2A1
      Related
      ENSMNEP00000029966.1, ENSMNET00000054380.1
      Conserved Domains (6) summary
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:107 → 222
      FERM_M; FERM central domain
      pfam00769
      Location:347 → 579
      ERM; Ezrin/radixin/moesin family
      pfam09379
      Location:26 → 86
      FERM_N; FERM N-terminal domain
      cl02098
      Location:334 → 487
      14-3-3; 14-3-3 domain

    2. XM_011750672.2 → XP_011748974.1  merlin isoform X3

      UniProtKB/TrEMBL
      A0A2K6D2A1
      Conserved Domains (6) summary
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:107 → 222
      FERM_M; FERM central domain
      pfam00769
      Location:347 → 524
      ERM; Ezrin/radixin/moesin family
      pfam09379
      Location:26 → 86
      FERM_N; FERM N-terminal domain
      cl02098
      Location:334 → 487
      14-3-3; 14-3-3 domain

    3. XM_011750669.2 → XP_011748971.1  merlin isoform X1

      UniProtKB/TrEMBL
      A0A2K6D205, A0A2K6D2A1
      Related
      ENSMNEP00000029951.1, ENSMNET00000054365.1
      Conserved Domains (6) summary
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:107 → 222
      FERM_M; FERM central domain
      pfam00769
      Location:347 → 595
      ERM; Ezrin/radixin/moesin family
      pfam09379
      Location:26 → 86
      FERM_N; FERM N-terminal domain
      cl02098
      Location:334 → 487
      14-3-3; 14-3-3 domain

    RNA

    1. XR_990705.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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