TGFB1 transforming growth factor beta 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: TGFB1provided by CGNC
Full Name: transforming growth factor beta 1provided by CGNC
Primary source: CGNC:65904
See related: Ensembl:ENSGALG00010008327
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: TGFB4; TGF-beta4
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 38

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	38	NC_052569.1 (279619..285137)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	38 Unlocalized Scaffold	NW_024096225.1 (62327..67911, complement)

Chromosome 38 - NC_052569.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects in broiler hens of genetic lines differing in fertility, biotin supplementation, and age on relative abundance of oviductal transforming growth factor-beta and carbonic anhydrase mRNA transcripts.
Title: Effects in broiler hens of genetic lines differing in fertility, biotin supplementation, and age on relative abundance of oviductal transforming growth factor-β and carbonic anhydrase mRNA transcripts.
the interactions of BMP and TGFbeta with polarity proteins dynamically modulate median hinge point formation.
Title: Cell-cycle-dependent TGFβ-BMP antagonism regulates neural tube closure by modulating tight junctions.
Taken together, these results suggest that staurosporine induces chondrogenesis through TGF-beta pathways including canonical Smads and non-canonical Akt and p38 MAPK signaling.
Title: Staurosporine induces chondrogenesis of chick embryo wing bud mesenchyme in monolayer cultures through canonical and non-canonical TGF-β pathways.
Cooperative effects have been found of FOXL2 with the members of TGF-beta superfamily on FSH receptor mRNA expression and granulosa cell proliferation from hen prehierarchical follicles.
Title: Cooperative Effects of FOXL2 with the Members of TGF-β Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.
There was a beneficial effect of Enterococcus faecium on IgA production and secretion in chicken intestine. IgA also contributed in decrease of intestinal Salmonella Enteritidis, and cytokines TGF-beta4 and IL-17 contributed to increased IgA secretion.
Title: Interaction of TGF-β4 and IL-17 with IgA secretion in the intestine of chickens fed with E. faecium AL41 and challenged with S. Enteritidis.
Data show that TGF-beta1, -beta2, and -beta3 and their receptors have distinct spatiotemporal developmental protein localization patterns in the developing tendon and suggest that these isoforms have independent roles in tendon development.
Title: Spatiotemporal protein distribution of TGF-betas, their receptors, and extracellular matrix molecules during embryonic tendon development.
TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures
Title: Embryonic expression of the transforming growth factor beta ligand and receptor genes in chicken.
mRNA expression of genes of the TGF beta family and endothelin 1 in lung samples from 4-week-old chickens with pulmonary hypertension, were determined.
Title: Over, and underexpression of endothelin 1 and TGF-beta family ligands and receptors in lung tissue of broilers with pulmonary hypertension.
what was once called chicken "TGFB4" is actually TGFB1
Title: On reassessment of the chicken TGFB4 gene as TGFB1.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables type II transforming growth factor beta receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables type III transforming growth factor beta receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transforming growth factor beta-1 proprotein

Names: TGF-beta-1; tissue growth factor-beta4; transforming growth factor beta 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318456.1 → NP_001305385.1 transforming growth factor beta-1 proprotein precursor

Status: PROVISIONAL

Source sequence(s)

JQ423909

UniProtKB/Swiss-Prot

A0A1D5PM67, P09531

UniProtKB/TrEMBL

A0A8V0Y611, H9CX01

Related

ENSGALP00010011469.1, ENSGALT00010019921.1

Conserved Domains (2) summary

smart00204
Location:295 → 392

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:21 → 261

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052569.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

279619..285137

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NW_024096225.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

62327..67911 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046937641.1 → XP_046793597.1 transforming growth factor beta-1 proprotein isoform X1

UniProtKB/Swiss-Prot

A0A1D5PM67, P09531

UniProtKB/TrEMBL

A0A8V0Y611, H9CX01