ARHGAP22 Rho GTPase activating protein 22 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ARHGAP22provided by VGNC
Official Full Name: Rho GTPase activating protein 22provided by VGNC
Primary source: VGNC:VGNC:52984
See related: Ensembl:ENSCAFG00845019760
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	28	NC_051832.1 (595180..731152, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	28	NC_006610.4 (648824..784583, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	28	NC_049249.1 (561465..697162, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	28	NC_049288.1 (394859..530643, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	28	NC_049769.1 (436100..571773, complement)

Chromosome 28 - NC_051832.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: rho GTPase-activating protein 22; LOW QUALITY PROTEIN: rho GTPase-activating protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051832.1 Reference ROS_Cfam_1.0

Range

595180..731152 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038439749.1 → XP_038295677.1 rho GTPase-activating protein 22 isoform X2

UniProtKB/TrEMBL

A0A8C0NYD8, A0A8C0Z3M0, A0A8I3PB74

Related

ENSCAFP00845027596.1, ENSCAFT00845035252.1

Conserved Domains (4) summary

COG1196
Location:556 → 637

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK07764
Location:310 → 525

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd04390
Location:108 → 306

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:36 → 121

PH-like; Pleckstrin homology-like domain
XM_038439748.1 → XP_038295676.1 rho GTPase-activating protein 22 isoform X4

UniProtKB/TrEMBL

A0A8C0TA60

Related

ENSCAFP00845027418.1, ENSCAFT00845035014.1

Conserved Domains (4) summary

COG1196
Location:599 → 680

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK07764
Location:353 → 568

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd04390
Location:151 → 349

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:36 → 151

PH-like; Pleckstrin homology-like domain
XM_038439747.1 → XP_038295675.1 rho GTPase-activating protein 22 isoform X1

UniProtKB/TrEMBL

A0A8C0NXV8, A0A8C0TA60, A0A8I3P622

Related

ENSCAFP00845027499.1, ENSCAFT00845035132.1

Conserved Domains (4) summary

COG1196
Location:615 → 696

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK07764
Location:369 → 584

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd04390
Location:167 → 365

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:36 → 151

PH-like; Pleckstrin homology-like domain
XM_038439750.1 → XP_038295678.1 rho GTPase-activating protein 22 isoform X3

UniProtKB/TrEMBL

A0A8C0P8M3

Related

ENSCAFP00845027738.1, ENSCAFT00845035437.1

Conserved Domains (4) summary

COG1196
Location:509 → 590

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK07764
Location:263 → 478

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd04390
Location:61 → 259

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:18 → 61

PH-like; Pleckstrin homology-like domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049288.1 Alternate UMICH_Zoey_3.1

Range

394859..530643 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038514371.1 → XP_038370299.1 rho GTPase-activating protein 22 isoform X2
XM_038514370.1 → XP_038370298.1 rho GTPase-activating protein 22 isoform X4
XM_038514369.1 → XP_038370297.1 rho GTPase-activating protein 22 isoform X1
XM_038514372.1 → XP_038370300.1 rho GTPase-activating protein 22 isoform X3

Conserved Domains (4) summary

COG1196
Location:509 → 590

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK07764
Location:260 → 478

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd04390
Location:61 → 259

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:18 → 61

PH-like; Pleckstrin homology-like domain

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049769.1 Alternate UNSW_CanFamBas_1.0

Range

436100..571773 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038642182.1 → XP_038498110.1 LOW QUALITY PROTEIN: rho GTPase-activating protein 22 isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049249.1 Alternate UU_Cfam_GSD_1.0

Range

561465..697162 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038578023.1 → XP_038433951.1 rho GTPase-activating protein 22 isoform X2

UniProtKB/TrEMBL

A0A8C0Z3M0
XM_038578022.1 → XP_038433950.1 rho GTPase-activating protein 22 isoform X4

UniProtKB/TrEMBL

A0A8C0TA60
XM_038578021.1 → XP_038433949.1 rho GTPase-activating protein 22 isoform X1

UniProtKB/TrEMBL

A0A8C0TA60
XM_038578024.1 → XP_038433952.1 rho GTPase-activating protein 22 isoform X3

UniProtKB/TrEMBL

A0A8C0P8M3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

648824..784583 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038460408.1 → XP_038316336.1 rho GTPase-activating protein 22 isoform X2

UniProtKB/TrEMBL

A0A8C0Z3M0, A0A8P0PID5

Conserved Domains (4) summary

COG1196
Location:556 → 637

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK07764
Location:307 → 525

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd04390
Location:108 → 306

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:36 → 121

PH-like; Pleckstrin homology-like domain
XM_038460407.1 → XP_038316335.1 rho GTPase-activating protein 22 isoform X4

UniProtKB/TrEMBL

A0A8C0TA60

Conserved Domains (4) summary

COG1196
Location:599 → 680

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK07764
Location:350 → 568

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd04390
Location:151 → 349

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:36 → 151

PH-like; Pleckstrin homology-like domain
XM_038460406.1 → XP_038316334.1 rho GTPase-activating protein 22 isoform X1

UniProtKB/TrEMBL

A0A8C0TA60, A0A8P0NRP5

Conserved Domains (4) summary

COG1196
Location:615 → 696

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK07764
Location:366 → 584

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd04390
Location:167 → 365

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:36 → 151

PH-like; Pleckstrin homology-like domain
XM_038460409.1 → XP_038316337.1 rho GTPase-activating protein 22 isoform X3

UniProtKB/TrEMBL

A0A8C0P8M3

Conserved Domains (4) summary

COG1196
Location:509 → 590

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK07764
Location:260 → 478

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd04390
Location:61 → 259

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:18 → 61

PH-like; Pleckstrin homology-like domain