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    adamts6 ADAM metallopeptidase with thrombospondin type 1 motif 6 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100490362, updated on 25-Apr-2024

    Summary

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    Official Symbol
    adamts6provided by Xenbase
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 6provided by Xenbase
    Primary source
    Xenbase:XB-GENE-951750
    See related
    Ensembl:ENSXETG00000000457
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Orthologs
    human mouse all
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    Genomic context

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    See adamts6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (187884629..188045191)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (175092868..175253647)

    Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene centromere protein K Neighboring gene CWC27 spliceosome-associated protein Neighboring gene SREK1-interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      187884629..188045191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002934207.5 → XP_002934253.2  A disintegrin and metalloproteinase with thrombospondin motifs 6

      See identical proteins and their annotated locations for XP_002934253.2

      UniProtKB/TrEMBL
      A0A6I8R5U5, F6YQE5
      Conserved Domains (6) summary
      smart00209
      Location:562 → 614
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:251 → 466
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:43 → 191
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:718 → 830
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1084 → 1116
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:481 → 549
      ADAM_CR_2; ADAM cysteine-rich domain

    2. XM_012967138.3 → XP_012822592.1  A disintegrin and metalloproteinase with thrombospondin motifs 6

      See identical proteins and their annotated locations for XP_012822592.1

      UniProtKB/TrEMBL
      A0A6I8R5U5, F6YQE5
      Related
      ENSXETP00000076547.1, ENSXETT00000073008.2
      Conserved Domains (6) summary
      smart00209
      Location:562 → 614
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:251 → 466
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:43 → 191
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:718 → 830
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1084 → 1116
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:481 → 549
      ADAM_CR_2; ADAM cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

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