pik3r3b phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3r3bprovided by ZNC
Official Full Name: phosphoinositide-3-kinase, regulatory subunit 3b (gamma)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-743
See related: Ensembl:ENSDARG00000034409 AllianceGenome:ZFIN:ZDB-GENE-040426-743
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pik3r3; zgc:55564; zgc:85710
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; and regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within phosphorylation. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in immature eye; nervous system; neural tube; periderm; and somite. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (33370895..33558977)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (33261168..33574287)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc34e10.x1 (e-PCR)
- UniSTS:193607

fi69e02.y1 (e-PCR)
- UniSTS:197869

Clone Names

MGC55564, MGC85710, MGC173784, MGC174729

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell development	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: phosphatidylinositol 3-kinase regulatory subunit gamma; phosphoinositide-3-kinase, regulatory subunit 3b (gamma)

Names: phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201143.2 → NP_957437.2 phosphoinositide-3-kinase, regulatory subunit 3b (gamma)

See identical proteins and their annotated locations for NP_957437.2

Status: PROVISIONAL

Source sequence(s)

BC081552

UniProtKB/TrEMBL

Q66I41

Related

ENSDARP00000040333.5, ENSDART00000040334.6

Conserved Domains (4) summary

cd09930
Location:353 → 456

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:61 → 169

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12925
Location:174 → 334

iSH2_PIK3R3; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 3, PIK3R3, also called p55gamma

pfam16454
Location:173 → 332

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

33370895..33558977

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476737.1 → XP_021332412.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

UniProtKB/TrEMBL

A0A8M9PLR5

Conserved Domains (4) summary

cd09930
Location:409 → 512

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:117 → 225

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12925
Location:230 → 390

iSH2_PIK3R3; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 3, PIK3R3, also called p55gamma

cl02570
Location:2 → 94

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
XM_005166277.4 → XP_005166334.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2

UniProtKB/TrEMBL

A0A8M2BDR6

Conserved Domains (4) summary

cd09930
Location:327 → 430

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:35 → 143

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

pfam16454
Location:147 → 306

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

cl23765
Location:148 → 308

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394654.1 Reference GRCz11 ALT_DRER_TU_1

Range

52280..74015

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395258.1 Reference GRCz11 ALT_DRER_TU_2

Range

107557..281272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474103.1 → XP_021329778.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3

UniProtKB/TrEMBL

A0A8M9PRX4

Conserved Domains (2) summary

cl02570
Location:116 → 307

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl17036
Location:7 → 77

SH3; Src Homology 3 domain superfamily