Transcription factor CHOP null mutation effect on fibroblasts subjected to ER stress: time course
Summary:
Expression profiling of embryonic fibroblasts deleted for the transcription factor CHOP. Fibroblast treated with 2 ug/ml tunicamycin for 4 or 8 hours to induce endoplasmic reticulum (ER) stress. Results provide insight into molecular mechanisms regulating the response to ER stress.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Marciniak SJ, Yun CY, Oyadomari S, Novoa I et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 2004 Dec 15;18(24):3066-77. PMID: 15601821
