Hormone-induced adipogenesis suppressed by 2,3,7,8-tetrachlorodibenzo-p-dioxin and EGF
Summary:
Analysis of differentiated C3H10T1/2 fibroblasts treated with 10 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and/or 10 nM EGF. Prior to treatment, cells induced to differentiate into adipocytes with IDMB hormone. EGF increases effectiveness of TCDD in suppressing hormone-induced adipogenesis.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citations:
Hanlon PR, Zheng W, Ko AY, Jefcoate CR. Identification of novel TCDD-regulated genes by microarray analysis. Toxicol Appl Pharmacol 2005 Feb 1;202(3):215-28. PMID: 15667827
Hanlon PR, Cimafranca MA, Liu X, Cho YC et al. Microarray analysis of early adipogenesis in C3H10T1/2 cells: cooperative inhibitory effects of growth factors and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 2005 Aug 22;207(1):39-58. PMID: 16054899
