Transcription factor engrailed-2 loss-of-function model of autism spectrum disorder: hippocampus
Summary:
Analysis of hippocampal samples from engrailed-2 (En2) mutant adults. The En2-/- animals are a model for autism spectrum disorder (ASD). The hippocampus is a brain area profoundly affected in ASD patients. Results provide insight into molecular mechanisms underlying ASD-related neuropathology.
Sgadò P, Provenzano G, Dassi E, Adami V et al. Transcriptome profiling in engrailed-2 mutant mice reveals common molecular pathways associated with autism spectrum disorders. Mol Autism 2013 Dec 19;4(1):51. PMID: 24355397
