Macrophage-restricted interleukin-10 receptor deficiency effect on colonic resident macrophages
Summary:
Analysis of FACS-sorted, interleukin-10 receptor (IL-10R)-deficient intestinal macrophages from 6-week-old C57BL/6 animals. IL-10 is a pleiotropic anti-inflammatory cytokine. Results provide insight into the role of IL-10 sensing by intestinal macrophages in gut homeostasis.
Zigmond E, Bernshtein B, Friedlander G, Walker CR et al. Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. Immunity 2014 May 15;40(5):720-33. PMID: 24792913
