Chronic high-calorie diet effect on Kras-driven lung tumors
Summary:
Analysis of lung tumors isolated from mice that develop KRAS-driven lung tumors. The KrasG12D mice were fed a high-calorie diet (HCD) starting 12 wk before tumor induction; tumors were collected 11 wk after tumor induction. Results provide insight into HCD effects on KRAS-driven lung tumorigenesis.
Ramadori G, Konstantinidou G, Venkateswaran N, Biscotti T et al. Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis. Cell Metab 2015 Jan 6;21(1):117-25. PMID: 25533479
