Analysis of p65+/+Ras and p65-/-Ras cells generated by infecting NF-κB subunit p65+/+ and p65-/- MEFs with pBabe-HRASG12V. Post-injection of the Ras cells into SCID mice, RasT tumors were removed, reconstituted in culture and examined. Results provide insight into role of NF-κB in tumorigenesis.
Wang DJ, Ratnam NM, Byrd JC, Guttridge DC. NF-κB functions in tumor initiation by suppressing the surveillance of both innate and adaptive immune cells. Cell Rep 2014 Oct 9;9(1):90-103. PMID: 25263557
