TGFβ-activated kinase 1 deficiency effect on liver
Summary:
Analysis of liver from 4-week old C57BL/6 males with hepatocyte-specific deletion of TGFβ-activated kinase 1 (TAK1). In hepatocytes, TAK1 controls activation of both IKK/NF-κB and JNK pathways. Results provide insight into the role of TAK1 in liver pathophysiology.
Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L et al. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 2014 Aug;124(8):3566-78. PMID: 24983318
