Histone/protein acetyltransferase (HAT) deficiency effect on Foxp3+ T-regulatory cells
Summary:
Analysis of CD4+CD25+ T regulatory (Treg) cells from C57Bl/6 mice deficient in p300 or CBP (a p300 paralog). p300 and CBP are histone/protein acetyltransferases (HATs). Results provide insight into mechanisms by which HATs affect Treg biology.
Liu Y, Wang L, Han R, Beier UH et al. Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function. Mol Cell Biol 2014 Nov;34(21):3993-4007. PMID: 25154413
