Caspase-8 defieciency effect on intestinal epithelial cells
Summary:
Analysis of intestinal epithelial cells from animals with an intestinal epithelium specific deletion of caspase-8, a cysteine protease involved in regulating cellular apoptosis. Results provide insight into the role of caspase-8 in the intestinal epithelium.
Günther C, Martini E, Wittkopf N, Amann K et al. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature 2011 Sep 14;477(7364):335-9. PMID: 21921917
