Pancreatic and duodenal homeobox 1 overexpression effect on primary pancreatic islets
Summary:
Analysis of primary islets transduced with adenovirus overexpressing pancreatic and duodenal homeobox 1 (Pdx-1). Homeodomain transcription factor Pdx-1 has key roles in pancreatic development and β-cell function. Results provide further insight into the role of Pdx-1 in pancreatic islets.
GPL1355:
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Citation:
Hayes HL, Moss LG, Schisler JC, Haldeman JM et al. Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. Mol Cell Biol 2013 Oct;33(20):4017-29. PMID: 23938296
