c-Jun N-terminal kinase-1 deletion effect on bile duct ligation model of liver fibrosis: time course
Summary:
Analysis of liver from c-Jun N-terminal kinase-1 null (Jnk1-/-) and hepatocyte-specific, JNK1 null (Jnk1Δhepa) males subjected to BDL for up to 28 days to induce liver fibrosis. Liver injury activates Jnk members of the MAPK family. Results provide insight into the role of Jnk1 in liver fibrosis.
Zhao G, Hatting M, Nevzorova YA, Peng J et al. Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis. Gut 2014 Jul;63(7):1159-72. PMID: 24037431
