Analysis of livers of mitochondrial protein deacetylase SIRT3 null mutants on a high fat diet (HFD). SIRT3 null mutants on a HFD exhibit obesity, insulin resistance, hyperlipidemia, and steatohepatitis. Results provide insight into molecular basis of metabolic dysfunction in SIRT3-deficient livers.
Hirschey MD, Shimazu T, Jing E, Grueter CA et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell 2011 Oct 21;44(2):177-90. PMID: 21856199
