Cmah knockout effect on mdx model of Duchenne Muscular Dystrophy (DMD): cardiac muscle
Summary:
Analysis of muscle from mdx males with a human-specific deletion in the Cmah (cytidine monophosphate-sialic acid hydroxylase) gene. Cmah-/-mdx mice show increased disease severity that better approximates DMD in humans. Results provide insight into the contributions of glycosylation defects to DMD.
Chandrasekharan K, Yoon JH, Xu Y, deVries S et al. A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Sci Transl Med 2010 Jul 28;2(42):42ra54. PMID: 20668298
