TYK2 and STAT1 silencing effect on JURKAT T-cell acute lymphoblastic leukemia cell line
Summary:
Analysis of JURKAT cells transduced with TYK2 and STAT1 shRNAs. JAK tyrosine kinase TYK2 and downstream effector STAT1 promote survival of T-ALL cells. Results provide insight into the molecular mechanisms underlying TYK2-STAT1 pathway dependence in T-cell ALL.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Sanda T, Tyner JW, Gutierrez A, Ngo VN et al. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov 2013 May;3(5):564-77. PMID: 23471820
