Palatal mesenchymal cells response to TGFβ2 stimulation in the presence of Tak1 kinase and TGFβRI inhibitors
Summary:
Analysis of palatal mesenchymal cells treated with TGFβ-activated kinase 1 (Tak1) inhibitor or TGFβ type I receptor (TGFβRI) kinase inhibitor for 1hr and then stimulated with TGF-β2 for 2 hrs. Results provide insight into TGFβ signaling mechanisms involved in craniofacial development.
Yumoto K, Thomas PS, Lane J, Matsuzaki K et al. TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells. J Biol Chem 2013 May 10;288(19):13467-80. PMID: 23546880
