Dicer1 deletion effect on bone marrow granulocyte-macrophage progenitors
Summary:
Analysis of bone marrow-derived GMPs from Dicer1-deficient, C57BL/6 females. Dicer1 encodes an RNaseIII enzyme critical for miRNA biogenesis. Dicer1-deficient GMPs are defective in myeloid development in vitro. Results provide insight into the role of miRNAs in myeloid-lineage specification.
Alemdehy MF, van Boxtel NG, de Looper HW, van den Berge IJ et al. Dicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in mice. Blood 2012 May 17;119(20):4723-30. PMID: 22353998
