Activated Autoimmune Regulator (AIRE)-deficient, CD8+CD28low regulatory T lymphocytes
Summary:
Analysis of AIRE-deficient, CD8+CD28low regulatory T (Treg) cells stimulated with allogeneic antigen-presenting cells (APC) and anti-CD3 antibody. Results provide insight into the role of AIRE in the function of regulatory T-cell populations, which are central to the prevention of immunopathology.
Pomié C, Vicente R, Vuddamalay Y, Lundgren BA et al. Autoimmune regulator (AIRE)-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis. Proc Natl Acad Sci U S A 2011 Jul 26;108(30):12437-42. PMID: 21746930
