Natural and induced Foxp3+ regulatory T cells and Foxp3-deficient induced regulatory T cells
Summary:
Analysis of 3 subsets of sorted Tregs: natural (nTreg), induced (iTreg), and iTregs that lost Foxp3 expression (ex-iTreg), from spleens and mesenteric lymph nodes of BALB/c Rag1-/- mice treated with WT nTregs and WT iTregs. Results provide insight into molecular relationships among the Treg subsets.
Schmitt EG, Haribhai D, Williams JB, Aggarwal P et al. IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. J Immunol 2012 Dec 15;189(12):5638-48. PMID: 23125413
