Analysis of CD34+CD38- and CD34+CD38+ cell fractions isolated from 5 acute myeloid leukemia (AML) patients. AML CD34+CD38- cells are enriched leukemic stem cells (LSC) that maintain the propagation of the disease. Results provide insight into molecular mechanisms that maintain and characterize LSC.
GPL571:
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Citation:
Gal H, Amariglio N, Trakhtenbrot L, Jacob-Hirsh J et al. Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells. Leukemia 2006 Dec;20(12):2147-54. PMID: 17039238
