Keratin 6a+, K6-tva RCAS-PyMT transgenic model of breast cancer
Summary:
Analysis of RCAS-PyMT-induced mammary tumors from K6-tva and MMTV-tva transgenic FVB/N mice. Tumors in the K6a-tva line resemble the normal breast-like subtype of human breast cancer, offering a tool to study the evolution of normal-like breast cancer.
Bu W, Chen J, Morrison GD, Huang S et al. Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene 2011 Oct 27;30(43):4399-409. PMID: 21532625
