TGF-beta/Smad3 signaling blockade effect on white adipose tissue
Summary:
Analysis of WAT from high fat diet-fed Smad3-/- mice and anti-TGF-beta antibody-treated, diet-induced obese (DIO) mice. Smad3 loss protects against DIO and diabetes. TGF-b signaling blockade protects against obesity and diabetes. Results provide insight into molecular mechanisms underlying diabetes.
Yadav H, Quijano C, Kamaraju AK, Gavrilova O et al. Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab 2011 Jul 6;14(1):67-79. PMID: 21723505
