Hypoxia effect on monocyte-derived, mature dendritic cells
Summary:
Analysis of mature dendritic cells (mDC) generated from monocytes under chronic hypoxia (1%O2). Hypoxia is a common feature at pathologic sites that creates a unique microenvironment affecting cell phenotype and behavior. Results provide insight into the impact of chronic hypoxia on mDC development.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Bosco MC, Pierobon D, Blengio F, Raggi F et al. Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo. Blood 2011 Mar 3;117(9):2625-39. PMID: 21148811
