Liver response to antagonism of endogenous microRNA-122 using a chemically modified antisense oligonucleotide: time course
Summary:
Analysis of liver from NMRI females treated with 25mg/kg LNA (locked nucleic acid)-antimiR-122 on day 2 and sacrificed at days 3, 9 and 23. Results provide insight into the utility of LNA-modified oligonucleotides in silencing miRNAs in vivo.
Elmén J, Lindow M, Silahtaroglu A, Bak M et al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res 2008 Mar;36(4):1153-62. PMID: 18158304
