Analysis of livers from 12-week old, chromogranin A knockouts (Chga KO). The Chga KO displays severe hypertension coupled with reduction in size, number, and density of regulated secretory granules. Results provide insight into the molecular basis of this monogenic hypertension model.
Friese RS, Gayen JR, Mahapatra NR, Schmid-Schönbein GW et al. Global metabolic consequences of the chromogranin A-null model of hypertension: transcriptomic detection, pathway identification, and experimental verification. Physiol Genomics 2010 Feb 4;40(3):195-207. PMID: 19952279
