Zinc finger transcription factor Gata4 inactivation effect on endothelial-derived cells
Summary:
Analysis of atrioventricular canals (AVC) from E9.5 hearts with endocardial-restricted Gata4 inactivation. The mutant endothelium failed to undergo epithelial-mesenchymal transition (EMT), resulting in hypocellular AV cushions. Results provide insight into the role of Gata4 in endocardial cell EMT.
Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S et al. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 2006 Sep;133(18):3607-18. PMID: 16914500