Analysis of skeletal muscles of 4 to 5 month old males treated with an anti-myostatin antibody to inhibit myostatin activity. Myostatin null mutations lead to hypermuscularity. Results provide insight into the molecular effect of the post-developmental loss of myostatin activity on skeletal muscles.
Welle S, Burgess K, Mehta S. Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice. Am J Physiol Endocrinol Metab 2009 Mar;296(3):E567-72. PMID: 19141683
