X-linked inhibitor of apoptosis XIAP depletion effect on a colorectal cancer cell line
Summary:
Analysis of early and late passage HCT116 colon cancer cells depleted for X-linked inhibitor of apoptosis (XIAP). XIAP is overexpressed in the majority of NCI 60 cell lines compared to normal cells suggesting a potential role as a therapeutic target in a wide spectrum of malignancies.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Connolly K, Mitter R, Muir M, Jodrell D et al. Stable XIAP knockdown clones of HCT116 colon cancer cells are more sensitive to TRAIL, taxanes and irradiation in vitro. Cancer Chemother Pharmacol 2009 Jul;64(2):307-16. PMID: 19034449
