PPARalpha deficient heart response to chronic pressure overload
Summary:
Analysis of heart left ventricles subjected to chronic pressure overload for 28 days to induce cardiac hypertrophy. PPARalpha mitigates cardiac hypertrophy. Results provide insight into processes and signalling pathways regulated by PPARalpha in hearts challenged by chronic pressure overload.
Smeets PJ, de Vogel-van den Bosch HM, Willemsen PH, Stassen AP et al. Transcriptomic analysis of PPARalpha-dependent alterations during cardiac hypertrophy. Physiol Genomics 2008 Dec 12;36(1):15-23. PMID: 18812456
