Transcription factor STAT5b deficiency effect on the colon
Summary:
Analysis of colons of animals lacking the Signal Transducers and Activators of Transcription member STAT5b. STAT5b mutants are more susceptible to experimental colitis, associated with intestinal barrier function defects. Results provide insight into the role of STAT5b in colonic barrier function.
Han X, Ren X, Jurickova I, Groschwitz K et al. Regulation of intestinal barrier function by signal transducer and activator of transcription 5b. Gut 2009 Jan;58(1):49-58. PMID: 18687707
