Analysis of papillomas initiated by DMBA/TPA treatment of epidermal keratinocytes deficient for activating transcriptional factor 2 (ATF2). ATF2 mutant animals show increased susceptibility to papillomas relative to the WT counterparts. Results provide insight into the role of ATF2 in skin cancer.
Bhoumik A, Fichtman B, Derossi C, Breitwieser W et al. Suppressor role of activating transcription factor 2 (ATF2) in skin cancer. Proc Natl Acad Sci U S A 2008 Feb 5;105(5):1674-9. PMID: 18227516
