Oxidative stress effect on ATF4 knockout embryonic neurons
Summary:
Analysis of bZip transcription factor activating transcription factor 4 (ATF4)-deficient, embryonic neurons treated with homocysteate (HCA), a glutamate analog that induces oxidative stress. Results provide insight into the role of ATF4 in oxidative stress-induced cell death.
Lange PS, Chavez JC, Pinto JT, Coppola G et al. ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. J Exp Med 2008 May 12;205(5):1227-42. PMID: 18458112
