Analysis of resting and activated natural killer (NK) cells. Activated NK cells can use the granule exocytosis pathway to kill target cells upon recognition, resting NK cells are minimally cytotoxic. Results provide insight into the molecular basis of the cytotoxicity displayed by NK cells.
Fehniger TA, Cai SF, Cao X, Bredemeyer AJ et al. Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity 2007 Jun;26(6):798-811. PMID: 17540585
